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Răspunsul imun mediat celular în cancerul pancreatic

  • Subiect: In the present study, we investigated the expression of HLA class I in human pancreatic carcinoma. The expression of HLA class I and the extent of tumour infiltration by different T-cells population were investigated in 31 pancreatic cancer patients by standard immunohistochemistry obtaining following types of expressions: negative in 33%, heterogeneous in 40% and positive in 27% of cases. Pancreatic carcinoma and tumour-surrounding tissue demonstrated a significantly higher infiltration by CD3+, CD4+ and CD8+ T-cells compared to the tumour-distant pancreatic tissue. The negative expression of HLA class I was uniformly accompanied by a low density of tumour-infiltrating cytotoxic T-cells whereas the HLA class I positive tumours were characterised by substantial lymphocyte accumulation. Pancreatic carcinoma induces frequently a cellular immune response which resulted in intra- and peritumoral T-cell infiltration.
  • Limba de redactare: română
  • Secţiunea: Medicină
  • Vezi publicația: Satu Mare - Studii şi Comunicări
  • Editura: Editura Muzeului Sătmărean
  • Loc publicare: Satu Mare
  • Anul publicaţiei: 2008
  • Referinţă bibliografică pentru nr. revistă: IX; anul 2008; seria Ştiinţele Naturii
  • Paginaţia: 82-88
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