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Controverse terapeutice în sindromul Turner

  • Subiect: Turner syndrome (TS) is a common genetic disorder, resulting from the partial or complete absence of one sex chromosome. It is associated with reduced adult height and with gonadal dysgenesis, leading to insufficient circulating levels of female sex steroids and to infertility. A number of recent studies have allowed new insights to be gained with respect to epidemiology, genetics, cardiology, endocrinology and metabolism. Elucidation of the effects of short stature homeobox protein deficiency has explained some of the phenotypic characteristics in TS, principally short stature. Treatment with growth hormone during childhood and adolescence allows a considerable gain in adult height, although the consequences of this treatment in the very long term are not clear. Puberty must be induced in most cases, and female sex hormone replacement therapy (HRT) is given during adult years. The optimal dose of HRT has not been established and, likewise, the benefits and drawbacks of HRT have not been thoroughly evaluated. In conclusion, TS is a condition associated with a number of diseases and conditions. Individuals with TS need life-long medical attention.
  • Limba de redactare: română
  • Secţiunea: Medicină
  • Vezi publicația: Satu Mare - Studii şi Comunicări
  • Editura: Editura Muzeului Sătmărean
  • Loc publicare: Satu Mare
  • Anul publicaţiei: 2007
  • Referinţă bibliografică pentru nr. revistă: VIII; anul 2007; seria Ştiinţele Naturii
  • Paginaţia: 148-150
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